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WHAT IS APDS?

Activated PI3Kδ syndrome (APDS) is a rare inborn error of immunity (IEI), which is characterised by both immune deficiency and immune dysregulation.1,2

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APDS IS PROGRESSIVE

APDS, previously known as PASLI*, is a progressive disease which can cause irreversible organ damage and lymphoma, resulting in early mortality.2-4

ACT NOW

Timely and accurate diagnosis of APDS is crucial to help limit its damage.
Act now to confirm a diagnosis via a genetic test.

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*P110d-Activating mutation causing Senescent T cells, Lymphadenopathy and Immunodeficiency.

  1. Lougaris V, et al. Pediatr Allergy Immunol. 2022;33 Suppl 27:69-72.
  2. Coulter TI, et al. J Allergy Clin Immunol. 2017;139(2):597-606.
  3. Elkaim E, et al. J Allergy Clin Immunol. 2016;138(1):210-218.
  4. Angulo I, et al. Science. 2013;342(6160):866-871.